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Pharmacology

Chair

  • Curt D. Sigmund

Professors

  • Mario Ascoli, Timothy Brennan, Frank Faraci, Rory Fisher, Donna L. Hammond, Donald Heistad, Raymond Hohl, A. Kim Johnson, Curt D. Sigmund, Stefan Strack

Associate professors

  • Christopher Benson, Minnetta Gardinier, Barry Kasson, John Koland, Anne Kwitek, Kathryn G. Lamping, Dawn E. Quelle, Frederick W. Quelle, Kamal Rahmouni, Yuriy Usachev

Assistant professors

  • Songhai Chen, Justin Grobe, D.P. Mohapatra, Matthew Potthoff, Qi Wu

Professors emeriti

  • Jeffrey Baron, Ranbir Bhatnagar, Gary R. Dutton, Gerald F. Gebhart, Ulla Kopp, Herbert K. Proudfit, Thomas Shires, Thomas Tephly, Harold Williamson
Graduate degrees: M.S.in pharmacology; Ph.D. in pharmacology
Web site: http://www.medicine.uiowa.edu/pharmacology/

The Department of Pharmacology provides professional training for health science students and participates with other departments in educational and research activities such as the Medical Scientist Training Program, the Physician Scientist Training Pathway, the Molecular and Cellular Biology Program, the Neuroscience Program, the Holden Comprehensive Cancer Center, the Iowa Cardiovascular Center, and the UI Fraternal Order of Eagles Diabetes Research Center.

The department was a pioneer in offering pharmacology to undergraduate students with little or no science background. Lectures in 071:120 (PCOL:2120) Drugs: Their Nature, Action, and Use emphasize the mechanisms of drug action and give students a background for rational decisions concerning use of drugs.

Pre- and postdoctoral students pursue research training in all areas of pharmacology in the department in preparation for career opportunities in academia, government, and industry.

Graduate Programs of Study

  • Master of Science in pharmacology
  • Doctor of Philosophy in pharmacology

Department of Pharmacology graduate study includes both didactic and research experience. Qualified students may pursue the joint M.D./Ph.D. in the University's Medical Scientist Training Program.

Master of Science

The Master of Science program in pharmacology requires a minimum of 30 s.h. of graduate credit. The program requires the following core courses.

071:135 (PCOL:5135) Principles of Pharmacology1 s.h.
071:136 (PCOL:5136) Pharmacogenetics and Pharmacogenomics1 s.h.
071:137 (PCOL:5137) Neurotransmitters1 s.h.
071:203 (PCOL:6090) Graduate Research in Pharmacologyarr.
071:204 (PCOL:6080) Pharmacology Seminar1 s.h.
071:302 (PCOL:6203) Pharmacology for Graduate Students6 s.h.
072:153 (MPB:5153) Graduate Physiology4 s.h.
099:243 (BIOC:5243) Protein Structure, Function, and Regulation: Biophysical Chemistry Module 11 s.h.
156:201 (BISC:5201) Fundamentals of Gene Expression1 s.h.
156:203 (BISC:5203) Fundamentals of Dynamic Cell Processes1 s.h.
156:204 (BISC:5204) Biostatistics for Biomedical Research1 s.h.

Students are expected to gain maximum experience in laboratory research while completing their course work. Satisfactory preparation and oral defense of a thesis based on the student's own research are required for completion of the program.

Doctor of Philosophy

The Doctor of Philosophy program in pharmacology requires a minimum of 72 s.h. of graduate credit. The program requires the following core courses.

071:135 (PCOL:5135) Principles of Pharmacology1 s.h.
071:136 (PCOL:5136) Pharmacogenetics and Pharmacogenomics1 s.h.
071:137 (PCOL:5137) Neurotransmitters1 s.h.
071:138 (PCOL:5138) Ion Channels1 s.h.
071:203 (PCOL:6090) Graduate Research in Pharmacologyarr.
071:204 (PCOL:6080) Pharmacology Seminar1 s.h.
071:208 (PCOL:6208) G Proteins and G Protein-Coupled Receptors1 s.h.
071:209 (PCOL:6209) Steroid Receptor Signaling1 s.h.
071:250 (PCOL:6250) Advanced Problem Solving in Pharmacological Sciences1 s.h.
071:302 (PCOL:6203) Pharmacology for Graduate Students6 s.h.
072:153 (MPB:5153) Graduate Physiology4 s.h.
099:243 (BIOC:5243) Protein Structure, Function, and Regulation: Biophysical Chemistry Module 11 s.h.
142:225 (MCB:6225) Growth Factor Receptor Signaling1 s.h.
156:201 (BISC:5201) Fundamentals of Gene Expression1 s.h.
156:203 (BISC:5203) Fundamentals of Dynamic Cell Processes1 s.h.
156:204 (BISC:5204) Biostatistics for Biomedical Research1 s.h.

Individual faculty research advisors may require additional courses.

During the first semester in the program, students are required to work in two different faculty laboratories before selecting a laboratory in which to pursue thesis research. Students then are expected to gain maximum laboratory research experience while completing course work. The Ph.D. comprehensive examination (written and oral) is given at the end of the fourth semester. Satisfactory preparation and oral defense of the thesis complete the program.

There is no departmental foreign language requirement.

Admission

Applicants must meet the admission requirements of the Graduate College; see the Manual of Rules and Regulations of the Graduate College or the Graduate College section of the Catalog. They should have a g.p.a. of at least 3.00 and a combined verbal and quantitative score of at least 312 on the Graduate Record Examination (GRE) General Test. They should have completed undergraduate courses in chemistry, biology, biochemistry, and mathematics.

Admission to the graduate programs is determined by the faculty after receipt of a completed formal application and interview (if appropriate) by faculty members or other designated individuals. Each application is reviewed individually. Some standard admission criteria may be waived for applicants who possess outstanding credentials in other areas.

Financial Support

The department provides all Ph.D. students and some M.S. students with financial support in the form of stipends and tuition support. Support is renewed annually based on satisfactory progress toward meeting degree requirements.

Courses

071:105 (PCOL:8203) Pharmacology for Health Sciences: Medical5 s.h.
Principles of pharmacology, pharmacologic actions of drugs, correlation with therapeutic uses. Offered fall semesters. Prerequisites: 050:240 (MED:8112) and 099:163 (BIOC:8103). Requirements: M.D. enrollment.
 
071:111 (PCOL:8240) Basic Pharmacology for Dental Students3 s.h.
Principles of pharmacology, pharmacologic actions of drugs, correlation with therapeutic uses. Offered spring semesters. Prerequisites: 072:152 (MPB:8115) and 099:161 (BIOC:8101). Requirements: D.D.S. enrollment.
 
071:115 (PCOL:6204) Pharmacology for Health Sciences: Nurse Anesthetist5 s.h.
Principles of pharmacology; pharmacologic actions of drugs, correlation with therapeutic uses. Offered fall semesters. Prerequisites: 060:270 (ACB:6000) or 096:270 (NURS:6000). Requirements: enrollment in Anesthesia Nursing Program.
 
071:120 (PCOL:2120) Drugs: Their Nature, Action, and Use2 s.h.
Principles of drug action, toxicity; sedatives, stimulants, hallucinogens, narcotics, over‑the‑counter agents, antibiotics, oral contraceptives. Offered spring semesters. Recommendations: closed to Pharm.D. students.
 
071:125 (PCOL:8225) Pharmacology for Health Sciences: Physician Assistant Students6 s.h.
Principles of pharmacology, pharmacologic actions of drugs, correlation with therapeutic uses. Offered fall semesters. Prerequisites: 099:164 (BIOC:8204). Requirements: Physician Assistant Studies and Services enrollment.
 
071:130 (PCOL:4130) Drug Mechanisms and Actions3 s.h.
Introduction to principles of pharmacology, pharmacologic actions of drugs. Offered spring semesters. Requirements: undergraduate biochemistry and physiology courses.
 
071:135 (PCOL:5135) Principles of Pharmacology1 s.h.
Basic pharmacological principles underlying drug absorption, drug distribution throughout the body, drug metabolism, and drug elimination; how these processes determine drug dosing and the means by which dosing parameters are characterized; drug receptor interactions and their quantitation. Offered spring semesters.
 
071:136 (PCOL:5136) Pharmacogenetics and Pharmacogenomics1 s.h.
Impact of genetic variation on the actions and metabolism of drugs; database search techniques to identify variants. Offered spring semesters. Prerequisites: 071:135 (PCOL:5135). Recommendations: undergraduate or graduate biochemistry.
 
071:137 (PCOL:5137) Neurotransmitters1 s.h.
Mechanisms of neurotransmission focusing on mechanisms of synthesis, regulation of release, mechanisms of action, means of degradation, and CNS pathways for major neurotransmitters; disease states involving various neurotransmitter systems. Offered spring semesters.
 
071:138 (PCOL:5138) Ion Channels1 s.h.
A heuristic, semiquantitative approach to concepts in ion channel physiology and pharmacology; discussions on up‑to‑date physical principles, classification, and structure/function relationships for major voltage‑gated ion channels that facilitate the application of abstract concepts to physiological, pharmacological, and general biological problems. Offered spring semesters.
 
071:180 (PCOL:8180) Pharmacology for Pharmacy Students I3 s.h.
Principles of pharmacology, toxicology; drug and toxic mechanisms; systemic and organ‑specific pharmacologic and toxic responses. Offered spring semesters. Requirements: first‑year Pharm.D. enrollment or graduate standing.
 
071:181 (PCOL:8181) Pharmacology for Pharmacy Students II3 s.h.
Continuation of 071:180 (PCOL:8180). Offered fall semesters. Requirements: second‑year Pharm.D. enrollment or graduate standing.
 
071:199 (PCOL:4199) Undergraduate Research in Pharmacologyarr.
Experimental research under faculty supervision in department laboratories.
 
071:203 (PCOL:6090) Graduate Research in Pharmacologyarr.
 
071:204 (PCOL:6080) Pharmacology Seminar1 s.h.
 
071:208 (PCOL:6208) G Proteins and G Protein-Coupled Receptors1 s.h.
Structure and function of small molecular weight G proteins; heteromeric G proteins and G protein‑coupled receptors. Offered spring semesters. Prerequisites: 099:243 (BIOC:5243), 156:201 (BISC:5201), and 156:203 (BISC:5203). Recommendations: 142:225 (MCB:6225).
 
071:209 (PCOL:6209) Steroid Receptor Signaling1 s.h.
Structure‑function relationship and genomic and nongenomic actions of the steroid hormone receptor family; basis for actions of novel new ligands on these receptors. Offered spring semesters. Same as 072:209 (MPB:6209), 132:209 (NSCI:6209).
 
071:210 (PCOL:6099) Special Topics in Pharmacologyarr.
 
071:215 (PCOL:6015) Topics in Neuropharmacology1 s.h.
Recent advances in neuropharmacology, developmental neurobiology, neuroendocrinology, and related neurosciences. Offered fall semesters.
 
071:220 (PCOL:6020) Topics in Pharmacogenomics1 s.h.
Recent advances in pharmacogenomics, pharmacogenetics, and related genetic fields. Offered fall semesters.
 
071:225 (PCOL:6025) Topics in Molecular Pharmacology1 s.h.
Recent advances in molecular pharmacology; receptor, postreceptor events in stimulus coupling.
 
071:231 (PCOL:6030) Topics in Cardiovascular Pharmacology1 s.h.
Recent advances in cardiovascular pharmacology, metabolic pharmacology, and related sciences. Offered spring semesters.
 
071:235 (PCOL:6035) Topics in Pain Analgesia1 s.h.
Recent advances in pain research, therapy.
 
071:250 (PCOL:6250) Advanced Problem Solving in Pharmacological Sciences1 s.h.
Discussion of methodologies, strategies, and approaches commonly used to solve pharmacological sciences problems; use of interpersonal problem‑solving skills to develop experimental study plans for solving contemporary scientific problems in pharmacology.
 
071:302 (PCOL:6203) Pharmacology for Graduate Students6 s.h.
Principles of pharmacology, pharmacologic actions of drugs, correlation with therapeutic uses. Offered fall semesters. Prerequisites: 072:153 (MPB:5153), 099:243 (BIOC:5243), 156:201 (BISC:5201), and 156:203 (BISC:5203).