Biomedical Engineering

College of Engineering

Biomedical Engineering Courses

Special Topics

051:000 Cooperative Education Training Assignment: Biomedical Engineering	0 s.h.
Biomedical engineering students participating in the Cooperative Education Program register for this course during work assignment periods; registration provides a record of participation in the program on the student's permanent record. Prerequisites: admission to Cooperative Education Program and consent of faculty advisor.

051:029 First-Year Seminar	1 s.h.
Small discussion class taught by a faculty member; topics chosen by instructor; may include outside activities (e.g., films, lectures, performances, readings, visits to research facilities). Prerequisite: first- or second-semester standing.

051:030 Cell Biology for Engineers	2 s.h.
Introduction to fundamental concepts in quantitative cell biology from an engineering perspective. Repeatable. Prerequisite: 002:010. Corequisites: 027:130 and 051:130.

051:040 Biological Systems Analysis I	3 s.h.
Application of principles of linear system (control) theory to analysis of biological systems; development of computer simulation techniques to study dynamic response of physiological systems. Offered fall semesters. Prerequisites: 22M:034, 027:130, and 051:130. Corequisite: 057:017.

051:050 Biomechanics: Theory and Design	3 s.h.
Introduction to biomechanics theory and design, with application to musculoskeletal and cardiovascular systems. Prerequisites: 027:130 and 057:019.

051:060 Data and Image Acquisition and Analysis	4 s.h.
Introduction to acquisition and analysis of data collected from living systems; concepts of analog and digital circuit design, with emphasis on circuits for collecting data for biomedical applications using operational amplifiers, active filters, conversion, and interface to microcomputers; patient safety; clinical circuits; analysis of data using time domain, spatial domain, and Fourier domain techniques; time domain and spatial domain sampling, Nyquist sampling theorem; physics, acquisition, and analysis of medical images, especially those collected from X-ray, CT, MR, and ultrasound systems. Prerequisites: 051:040, 057:017, and 059:008. Corequisite: 051:080.

051:062 Design for Manufacturing	3 s.h.
Same as 056:032, 058:032.

051:070 Biomaterials and Implant Design	3 s.h.
Properties, biocompatibility characteristics, performance requirements of materials for implants. Offered spring semesters. Prerequisites: 004:012 and 057:019. Corequisite: 051:075.

051:075 Cell-Material Interactions	3 s.h.
Current thought and techniques in engineering and assessment of biomaterials. Prerequisites: 027:130 and 051:030. Corequisite: 051:070.

051:080 Data Acquisition Design Laboratory	2 s.h.
Laboratory for 051:060; practice in designing and building electronic circuits to measure, acquire, and analyze biosignals, and in acquiring and analyzing images from the human body. Corequisite: 051:060.

051:085 Biomedical Engineering Senior Design I	4 s.h.
Individual or group work on a creative design project involving current problems in biomedical engineering; interdisciplinary projects involving biomedical engineering and health sciences faculty members; first semester of a year-long senior capstone design project. Prerequisites: 051:080 and senior standing.

051:086 Biomedical Engineering Senior Design II	4 s.h.
Second semester of a year-long senior capstone design project begun in 051:085. Prerequisites: 051:085 and senior standing.

051:090 First-Year Forum	0 s.h.
Presentations by faculty, graduate students, collaborators from the Carver College of Medicine, and Colleges of Dentistry and Law; may include visits to laboratories and industries.

051:091 Professional Seminar: Biomedical Engineering	0 s.h.
Professional aspects of biomedical engineering presented through lectures and discussions by guest speakers, field trips, films, panel discussions. Repeatable. Prerequisite: sophomore or higher standing.

051:092 Leadership and Resourcefulness	0 s.h.
Development of leadership skills and resourcefulness for real-world professional work and life. Repeatable. Prerequisite: completion of six semesters of 051:090 and 051:091 combined.

051:098 Individual Investigations: Biomedical Engineering	arr.
Individual projects for biomedical engineering undergraduate students, such as laboratory study, engineering design projects, analysis and simulation of an engineering system, computer software development, research. Prerequisite: consent of instructor.

051:121 Introduction to Bioinformatics	4 s.h.
Overview of bioinformatics and genome science including genome projects, functional genomics, phylogenetics, proteomics, microarray, DNA polymorphism, data-mining algorithms; experimental methods and analytical approaches. Prerequisite: consent of instructor. Same as 002:169, 055:121.

051:122 Computational Genomics	3 s.h.
Contemporary computational methods in genomics and molecular biology; DNA and RNA sequence analysis, sequence/gene/disease mapping, gene expression, disease gene linkage; principal genome science challenges, recent solutions. Prerequisite: 002:170 or 055:121 or 127:170. Same as 002:174, 055:122, 127:173.

051:123 Bioinformatics Techniques	3 s.h.
Tools and techniques relevant to bioinformatics and genomics with theoretical and design issues; genetics, algorithms, Perl, bio-Perl, XML, databases, datamining, systems software.

051:130 Cell Biology for Engineering Lab	1 s.h.
Cell biology-based studies of biochemical mechanisms, with emphasis on quantitative analysis. Corequisite: 027:130.

051:162 Digital Human Modeling and Simulation	3 s.h.
Fundamentals of using computational methods in modeling, simulating, and animating articulated kinematic chains such as robots and humans; underlying mathematics, introductory concepts in kinematics and dynamics, serial chain kinematics and multibody dynamics; methods from kinematics and dynamics, coupled with biomechanical concepts, provide an integrated approach to predicting and analyzing serial link motion (e.g., human and robotic manipulator motion). Prerequisite: 057:010. Same as 058:136.

051:178 Fast-Track Biomedical Engineering Design I	4 s.h.
First semester of year-long senior capstone design project; individual or group design project involving biomedical engineering problems. Prerequisites: 051:080 and senior standing.

051:179 Fast-Track Biomedical Engineering Design II	4 s.h.
Second-semester of year-long senior capstone design project begun in 051:178. Prerequisites: 051:178 and senior standing.

Biomaterials

051:168 Polymer Fundamentals	1 s.h.
Polymer fundamental principles, including polymer synthesis, characterization, molecular weight determination. Corequisite: 051:169. Same as 052:140.

051:169 Polymers as Biomaterials	2 s.h.
Structure-property relationships and in vivo and in vitro performances of polymers used to manufacture implants and other devices. Prerequisite: 051:070 or equivalent.

051:170 Graduate Biomaterials and Implant Design	3 s.h.
Properties, biocompatibility characteristics, performance requirements of materials for implants. Prerequisite: 004:012.

051:173 Metals as Biomaterials	3 s.h.
Property-structure relationship of metals used to fabricate implant materials; their interactions in vivo. Prerequisite: 051:070 or equivalent.

051:174 Ceramics and Glasses as Biomaterials	3 s.h.
Property-structure relationship of ceramics and glasses used to fabricate implant materials; their interactions in vivo. Prerequisite: 051:070 or equivalent.

051:175 Tissue Engineering	3 s.h.
Principles of tissue engineering; cell/material interactions, cellular scaffolding, material design for tissue-engineered devices, genetic engineering for tissue engineering, in vitro and in vivo models. Same as 046:290, 052:227.

051:176 Biomaterials Laboratory	3 s.h.
Practical experience in design, fabrication, and testing of biomaterials and devices; mechanical testing, tissue response, design to optimize response. Basic understanding of materials required. Prerequisite: 051:070.

051:177 Graduate Cell Material Interactions	3 s.h.
Current thought and techniques in the engineering and assessment of biomaterials; companion course to 051:070 and 051:075. Prerequisite: senior or graduate standing.

051:215 Interfacial Engineering for Biological Systems	3 s.h.
Survey of current literature on interfacial engineering for biomedical engineering; student presentation and discussion of articles. Prerequisite: organic or polymer chemistry or consent of instructor.

051:248 Elastic Waves in Solids	3 s.h.
Same as 053:248, 058:271.

Biomechanics/Biofluids

051:149 Graduate Biomechanics	3 s.h.
Understanding the human body from an engineering mechanics perspective; challenges of applying engineering principles to living systems, illustrated through real-world examples. Repeatable. Prerequisite: 057:019.

051:150 Musculoskeletal Biomechanics	3 s.h.
Principles of solid mechanics applied to analytical, experimental investigation of biological systems; emphasis on applications in kinesiology of human musculoskeletal system. Prerequisites: 057:019 and graduate standing.

051:151 Intermediate Mechanics of Deformable Bodies	3 s.h.
Application of equilibrium analysis, strain-displacement relations, constitutive relationships to practical structural systems and elementary plane elasticity problems. Offered fall semesters. Prerequisite: 057:019. Same as 053:140, 058:150.

051:152 Ergonomics of Occupational Injuries	3 s.h.
Epidemiology, surveillance systems, ergonomics, biomechanics, physiology, psychology, legal aspects, and cost control. Prerequisite: 051:050 or 051:150.

051:154 Cardiac and Vascular Mechanics	3 s.h.
Bio-solid mechanics of the cardiovascular system; mechanical properties of ventricles, valves, and blood vessels, their normal function, how they are affected by disease states; design of artificial organs, prostheses. Prerequisite: 057:019.

051:155 Cardiovascular Fluid Mechanics	3 s.h.
Anatomy and physiology of the human circulatory system, pressure-flow relationship in arteries, elastic properties of the arterial wall, steady and pulsatile flow dynamics, flow dynamics of human heart valves, flow dynamics past valve prostheses, fluid mechanical measurements in circulation, relationship between fluid mechanics and diseases in human circulation. Prerequisite: 057:019.

051:157 Introduction to Applied Biomedical Finite Element Modeling	3 s.h.
Introduction to finite element modeling as applied to biomechanics-related applications. Prerequisite: 051:050. Corequisites: 051:150 and 058:115.

051:158 Biomechanics of Orthopaedic Implants	3 s.h.
Design and function of hip, knee, ankle, shoulder, elbow, and wrist replacements and of fracture stabilization devices; fixation modalities, stress analysis, tissue adaptation, failure mechanisms. Prerequisites: 051:050, 057:019, 059:007, and 059:008.

051:253 Spine Mechanics	3 s.h.
Biomechanics applied to mechanics of the human spine; clinical aspects; state-of-the-art in spine research; basic engineering principles for biomechanical analysis. Prerequisite: 051:150.

051:254 Advanced Vascular Mechanics	3 s.h.
Topics in vascular solid mechanics; study of vascular tissue from theoretical (constitutive modeling), experimental, and computational perspectives. Prerequisite: 051:154.

051:255 Advanced Biofluid Mechanics	3 s.h.
Hemodynamic theories of atherogenesis, Womersley models, steady and unsteady flows in curavature, bifurcation and branching arterial segments, flow dynamics past prosthetic implants, experimental and computational models, particulate and mass transport simulations in human circulation. Prerequisite: 051:155.

051:257 FE Analysis in Orthopaedic Biomechanics	3 s.h.
Finite element modeling techniques applied to musculoskeletal (orthopaedic) biomechanics; use of ABAQUS finite element software. Prerequisite: 051:150. Corequisites: 051:158 and 058:115.

Bioelectrical Engineering

051:141 Graduate Biological Systems Analysis	3 s.h.
Application of principles of linear system (control) theory to analysis of biological systems; development of computer-simulation techniques to study dynamic response of physiological systems. Prerequisite: graduate standing.

051:148 Digital Image Processing	3 s.h.
Same as 055:148.

051:161 Graduate Data and Image Acquisition and Analysis	4 s.h.
Acquisition and analysis of data collected from living systems; concepts of analog and digital circuit design, with emphasis on circuits data collection for biomedical applications using operational amplifiers, active filters, conversion, and microcomputer interface; patient safety, clinical circuits, data analysis using time domain, spatial domain, Fourier domain techniques; time domain and spatial domain sampling, Nyquist sampling theorem; physics, acquisition, and analysis of medical images, with emphasis on X-ray, CT, MR, ultrasound. Prerequisite: 027:130 or equivalent. Corequisites: 051:141 and 051:181.

051:181 Graduate Data Acquisition Design Laboratory	2 s.h.
Corequisite laboratory for 051:161; practice in designing and building electronic circuits to measure, acquire, and analyze biosignals; and in acquiring and analyzing images obtained from the human body. Prerequisites: a basic electronics course and graduate standing. Corequisite: 051:161.

051:182 Biomedical Signal Processing	3 s.h.
Application of signal processing methods (e.g., Fourier, Laplace, z-transforms) to biomedical problems, such as analysis of cardiac signals, circadian rhythm, the breathing cycle; computer simulation lab. Prerequisite: 051:080.

051:185 Medical Imaging Physics	3 s.h.
Physics and data acquisition techniques of major medical imaging modalities (X-ray, CT, MR, ultrasound, PET, SPECT); physical interactions of energy with living tissue; principles and methods for acquiring imaging data and subsequent image construction; how individual modalities influence image quality; MATLAB programming required. Second in a medical imaging sequence. Prerequisites: background in physics and computers, and anatomy or biology or physiology.

051:186 Multidimensional Medical Imaging Process	3 s.h.
Algorithms developed to process and analyze large volumetric data sets; physics of CT, MRI, ultrasound, 3-D convolution and filtering, geometric transformations, shape features, surface segmentation, regional segmentation, surface tiling, surface reconstruction, volumetric registration. Third in a medical imaging sequence. Prerequisite: 051:185.

051:187 Health Informatics I	3 s.h.
Same as 021:275, 050:283, 056:186, 074:191, 096:283, 174:226.

051:188 Imaging Practicum	3 s.h.
Real-world problems in medical imaging; team approach leading to publication in scientific literature. Prerequisite: 051:060 or 051:185 or 051:186 or equivalent.

051:189 Health Informatics II	3 s.h.
Health care networking, computer-based patient records, network-based imaging and physiologic monitoring applications, information protocols and standards, network system design, validation techniques. Same as 021:280, 056:287, 074:192, 096:289.

051:280 Functional Magnetic Resonance Imaging	2-3 s.h.
Introduction to basic and advanced fMRI methods used in cognitive neuroscience; hands-on design and analysis of fMRI data. Same as 132:250.

051:286 Contemporary Topics in Medical Imaging	3 s.h.
Presentation of recent research results and clinical applications of medical imaging techniques. Prerequisites: 051:185, and 051:186 or equivalent.

051:287 Insight into Images	3 s.h.
Advanced image processing algorithms applied to analysis of medical images; image segmentation (level sets, watershed, active contours) and image registration (mutual information, Thirion Demons, B Spline algorithms); development and application of these algorithms using ITK Toolkit. Prerequisites: 051:158 and 051:186.

Graduate Seminars, Advanced Topics, Research

051:191 Seminar in Biomedical Engineering	0 s.h.
Presentation of recent advances in biomedical engineering. Prerequisite: graduate standing.

051:198 Individual Investigations: Biomedical Engineering	arr.
Individual projects for biomedical engineering graduate students, such as laboratory study, engineering design project, analysis and simulation of an engineering system, computer software development, research. Prerequisites: graduate standing and consent of advisor.

051:199 Research: Biomedical Engineering M.S. Thesis	arr.
Experimental and/or analytical investigation of an approved topic for partial fulfillment of the requirements for the M.S. with thesis in biomedical engineering. Prerequisites: graduate standing and consent of advisor.

051:298 Advanced Individual Investigations in Biomedical Engineering	arr.
Advanced individual projects such as laboratory study, engineering design projects, analysis and simulation of an engineering system, computer software development, research. Prerequisite: graduate standing.

051:299 Research: Biomedical Engineering Ph.D. Dissertation	arr.
Experimental and/or analytical investigation of an approved topic for partial fulfillment of requirements for Ph.D. with thesis in biomedical engineering. Prerequisite: consent of advisor.

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